Sardines & The No-Aging Diet


In 1979 Dr. Benjamin Frank published his classic text on resisting the ravages of time and remaining young- The No-Aging Diet. In short, the key to a longer life and even reversing the effects of aging, according to Dr. Frank – nucleic acid.

Ever heard of Dr. Benjamin S. Frank? Chances are good you haven’t. But his pioneering research on the remarkable health benefits of dietary nucleic acids (RNA, DNA, nucleotides, nucleosides) is changing the world of nutrition. In fact, it’s revolutionizing our understanding of it.

If you have heard of Dr. Frank, maybe you read his book, Dr. Frank’s No-Aging: Eat and Grow Younger. It was a New York Times bestseller in 1976.

Or maybe you saw his technical treatise, Dietary Nucleic Acid Nutrition and Therapy (1977). That was his masterpiece on the topic of dietary nucleic acids for health. (If you read it, then you’re probably a doctor, nutritionist, or health researcher.)

Perhaps you’ve come across articles on Dr. Frank’s RNA research by Ward Dean, MD or other doctors and scientists writing on advanced nutritional topics. Maybe you follow my blog posts, such as “9 Things To Know About Rejuvenate!™ Superfoods.”


Four important things to know about Dr. Benjamin S. Frank:

1) He pioneers the use of dietary nucleic acids as therapeutic agents in anti-aging and degenerative diseases

2) He proves that dietary nucleic acids are safe and effective natural means to support optimal health

3) He discovers and documents many beneficial effects through his research studies

4) He creates a simple diet based on high-RNA foods he recommends for individuals who wish to gain these benefits.

Dr. Frank performed numerous research experiments using humans and animals on health effects of dietary RNA. In fact, he was among the first to report significant health benefits with a dietary approach. In this respect, he is perhaps the founder of dietary nucleic acid therapy.

Today, Dr. Frank might win a Nobel Prize in Medicine. Because what his research shows about the health effects of dietary nucleic acids is nothing short of groundbreaking.

Nobel prizes are not awarded posthumously. But if they were, he would be an ideal candidate for nomination because of the incredible potential nucleic acids hold for improving human health. However, it is important to note that despite their amazing benefits, Dr. Frank never regarded dietary nucleic acids as medicines, but as natural nutrients essential to health.


Dr. Benjamin S. Frank was born in 1923 and became a physician in New York City. He was both a practicing medical doctor and a PhD molecular biologist. This fact made him uniquely qualified to study nucleic acids from both practical and theoretical perspectives. From the 1950s through the mid-1970s, Dr. Frank pioneered the use of dietary nucleic acids for therapeutic purposes in aging and degenerative diseases.

Dr. Frank was not the first to examine the effects on nucleic acids for boosting health. As Dr. Ward Dean has written, experiments with nucleic acids were performed early in the twentieth century. For example, Dr. C.S. Minot in 1908 was the first to propose that nucleic acids were vital for the cellular health of cells and essential for longevity.

In 1928, Dr. T. Brailsford Robertson in Australia presented the first experimental evidence that nucleic acids could promote longevity in a series of studies on mice. By the mid-1940s, Dr. Thomas Gardner at Hoffman-LaRoche replicated Dr. Robertson’s work with several modifications.

In the early 1970s, Dr. Max Odens performed experiments with RNA and DNA using rats that confirmed earlier work, and produced exceptional results. Other researchers (primarily in Europe) focused on using injectable organic-specific animal tissues containing nucleic acids as therapy for corresponding organs in humans.

Dr. Benjamin S. Frank


The contributions of Dr. Frank in many respects overshadow those of his predecessors and contemporaries in the realm of RNA research. He not only performed his research studies over the course of many years, but he also performed many of them using human subjects. It was his role as practicing physician that allowed him to see for himself the direct benefits his subjects gained from dietary nucleic acids.

Moreover, as I noted above, beyond experimenting with RNA extracts in his laboratory or confining the results of his human studies to technical works or scientific publications, Dr. Frank chose to develop concrete recommendations that anyone can follow. That is, he intentionally explores the RNA content of common foods in order to make the benefits accessible to ordinary people. He then builds the no-aging diet around foods providing the highest levels of dietary nucleic acids.

Dr. Frank acknowledges the work of earlier scientists and medical researchers who investigated nucleic acids and their role in health. Yet, he himself distinguishes his work stating:

“I aim at improving the health of the entire body rather than one organ or one disease at a time; my therapy involves both RNA and sometimes DNA; my patients take them orally, as in the diet, not by injection; and I regard nucleic acids not as medicines but as natural nutrients.” (73)

Dr. Frank’s writings often are technical and theoretical. But his focus on the practical aspects of nucleic acid therapy in Dr. Frank’s No-Aging Diet distinguish him from all previous nucleic acid researchers. This work is his accessible, highly readable guide to the dietary program he developed for his patients. As I noted previously, he fully intended his diet to be easy to follow by anyone.

It is the simplicity and practicality of Dr. Frank’s diet that makes his book compelling, as well as popular enough to be a bestseller. Not an easy feat.


Dr. Frank reports many health building, rejuvenating, and anti-aging effects of dietary nucleic acids. Direct benefits he observed include:

• Significant increase in “energy” or activity
• Anti-anoxic effects (i.e., reduced shortness of breath)
• Improved capacity to tolerate low temperatures
• Reduced skin wrinkling and increased skin elasticity
• Better cognitive performance
• Enhanced immunity

Dr. Frank also reports results he gains from using nucleic acids for a variety of health issues and specific conditions:

• Arthritis
• Atherosclerosis
• Hyperlipidemia
• Cancer
• Diabetes and complications
• Emphysema
• Colds
• Glaucoma
• Poor vision
• Retinitis pigmentosa
• Reduced skin wrinkles
• Acne
• Hair growth
• Psoriasis
• Diverticulitis
• Memory loss
• Parkinson’s Disease
• Bell’s Palsy
• Lupus erythematosus

This list is quite extensive and impressive. In Part Two of this article, I will expand on the mechanisms by which dietary nucleic acids support optimal health. I will also delve into the details of Dr. Frank’s no-aging diet recommendations in order to show how individuals can create their own ideal high-RNA diets.

The richest food sources of nucleic acid – the building blocks of DNA are as follows:


  • A number of different seafood options contain nucleic acids, particularly fish. According to the Gordon Research Institute, sardines have the highest levels of nucleic acids, which typically comprise 1.5 percent of the fishes’ total composition. In addition to animal-based seafood options, there are also plant-based foods that contain nucleic acids. According to AGM Foods, chlorella, a type of single-celled algae, is amongst these. The algae are also well known for their high levels of fatty acids and polysaccharides.


  • Nuts are excellent sources of proteins and unsaturated fats, which are good for heart function. According to the Gordon Research Institute, most varieties also have high levels of nucleic acids.


  • Vegetables are a staple food for proper nutrition, as—according to Harvard University—eating them can help regulate blood pressure and blood sugar levels, and can help prevent stroke, heart disease, digestive troubles, eyesight problems and cancer. According to the U.S. National Library of Medicine, many vegetables are good sources of nucleic acids. These include Chinese cabbage, broccoli, leeks, spinach, cauliflower, beans and soybeans.


  • Mushrooms are edible fungi that are known for being low in cholesterol, fat, calories and sodium; and for being high in nutrients like vitamin E and selenium. According to the U.S. National Library of Medicine, many mushrooms, such as flat, whitecap (button), cep and oyster mushrooms, also have high levels of nucleic acids.


  • According to the U.S. National Library of Medicine, hydrolyzed and autolyzed yeast, which food companies commonly add into microwavable vegetarian meals, are two strong sources of nucleic acids. They can also help increase your body’s production of purines, which are compounds that oxidize to form uric acid.


  • Beef is another good source of nucleic acids. According to the Gordon Research Institute, red meat is the best: and typically has a .05 percent nucleic acid content.

Broths / Soups

  • According to the Gordon Research Institute, soups and broths that contain vegetables, mushrooms and/or beef are also good sources of nucleic acids.









The Problem of Age, Growth and Death. C.S. Minot. Putnam’s Sons, 1908.

“On the influence of nucleic acids of various origin upon the growth and longevity of the white mouse. ” T. Brailsford Robertson. Australian J. Exp Biol Med Sci, 1928, 5: 47–67.

“The effect of yeast nucleic acid on the survival time of 600 day old albino mice.” Thomas Gardner. J Gerontol, 1946, 1: 445–456

“Prolongation of the life span in rats.” Max Odens. J. American Geriatrics Soc., 1973, XXI: 450–451.


Dr. Frank’s No-Aging Diet: Eat and Grow Younger. Dial Press, 1976.

Nucleic Acid Nutrition and Therapy. Rainstone Publishing, 1977

Nucleic Acid and Anti Oxidant Therapy of Aging and Degeneration. Royal Health Books, 1977.

Nucleic Acid Therapy in Aging and Degenerative Disease–A Metabolic Approach with DNA, RNA, and Related Metabolites. Psychological Library, 1968.


Ribonucleic Acid Part One: A Highly Effective Anti-Aging Supplement by Ward Dean

Ribonucleic Acid Part Two: Review of Potential Anti-Aging Effects by Ward Dean

Ribonucleic Acid Part Three: Potential Therapeutic Uses: Review of Clinical Experience with RNA by Ward Dean

Revisiting a Scientist’s Work: New Studies Reinforce Older Ones…RNA Therapy May Slow Down Aging by Jeffrey Laign


High-RNA Rejuvenate! Superfood by Hank Liers, PhD

9 Things to Know about Rejuvenate!™ Superfoods by Fred Liers, PhD


Super-Tasty Morning Nutritional Drinks by Dr. Hank Liers & Fred Liers, PhD

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